*__________________* SR-ASM algorithm is designed for DNA assembly of the short sequences coming from 454 sequencers. The 454 sequencer protocol is based on measuring light intensities generated during the sequencing process. The sequences are given as nucleotide chains with numbers of their consecutive appearances. Additionally to the sequences, one gets rates of confidence for every nucleotide. *__________________* Configuration ---------------- In config.h there are many parameters. Most significant are: PROC_NUM - how many processess HASH_LENGTH - length of hash COMPUTATIONAL_TRESHOLD - heuristic threshold which defines when pair of sequences should be decline to compare with SW algorithm SEQUENCE_BEGIN - maximum offset in overlapping sequences How to Install ---------------- Unpack file. Type 'make' in directory where program was unpacked. How to use ---------------- To use program you need a file with sequences given in fasta format and a file with qualities. In the quality file there should be given precision for all sequences in format: >sequence1 name q1_1 q1_2 q1_3 q1_4 .... >sequence2 name q2_1 q2_2 q2_3 q2_4 .... its very similar to fasta format, but instead of nucleotids there are given integer qualities separated by space To run program type for example: ./alignment.exe sample.fasta sample.qual > results 2>error.log where sampla.fasta - file with sequences sample.qual - file with qualities results - file where results should be written to error.log - file with debug information