What we actually do

The main areas of our research are: DNA sequencing and assembling (including design of algorithms for the NGS sequencers); protein structure analysis; RNA structure analysis and prediction (including automatic tertiary structure prediction tool); nanotechnology and DNA computing.

Proteins are the main building blocks of life. They catalyze biological processes in living cells to sustain life and improve metabolism. They also act as biological scaffolds and are cell's workhorses. As a matter of fact, knowing their function is one of the most important milestones for understanding life. The function depends on the tertiary structure of the protein, but only for a fraction of amino acid sequences gathered in databases the structure is known. Thus, creation of efficient and accurate methods that predict function from sequences, based on already known function-sequence assignments, is a fundamental challenge in computational biology. Another important issue concerning structure analysis is a development of reliable computational methods designed to evaluate the quality of predicted models, computing structure similarity and structure comparison. All of these issues are addressed in our research.

The main subjects undertaken by the group within the protein field are:
- protein structure prediction
- protein function prediction
- validation of predicted protein models
- protein sequence analysis
de novo peptide sequencing
- an analysis of RNA-protein complexes
- peptide-protein docking